Understanding Biomolecular Interactions at Interfaces

Interfaces, especially those that mimic biological membranes, are crucial to many systems we investigate. Our research explores how biomolecules, including peptides, interact with these interfaces and how these interactions influence processes such as antimicrobial activity and viral infection enhancement. Gaining insights into biomolecule-membrane interactions is vital for understanding biomolecular transport in cellular environments.

Related Publications

Torsten John, Stefania Piantavigna, Tiara J A Dealey, Bernd Abel, Herre Jelger Risselada, Lisandra L Martin (2023). Lipid oxidation controls peptide self-assembly near membranes through a surface attraction mechanism. Chemical Science. https://doi.org/10.1039/D3SC00159H

Torsten John, Tiara J A Dealey, Nicholas P Gray, Nitin A Patil, Mohammed A Hossain, Bernd Abel, John A Carver, Yuning Hong, Lisandra L Martin (2019). The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide’s Secondary Structure. Biochemistry. https://doi.org/10.1021/acs.biochem.9b00536

Torsten John, Bernd Abel, Lisandra L Martin (2018). The Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) Technique Applied to the Study of Membrane-Active Peptides. Australian Journal of Chemistry. https://doi.org/10.1071/CH18129

Lisandra L Martin, Clemens Kubeil, Stefania Piantavigna, Tarun Tikkoo, Nicholas P Gray, Torsten John, Antonio N Calabrese, Yanqin Liu, Yuning Hong, Mohammed A Hossain, Nitin Patil, Bernd Abel, Ralf Hoffmann, John H Bowie, John A Carver (2018). Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5. Peptide Science. https://doi.org/10.1002/pep2.24052

Torsten John, Trayder Thomas, Bernd Abel, Bayden R Wood, David K Chalmers, Lisandra L Martin (2017). How kanamycin A interacts with bacterial and mammalian mimetic membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes. https://doi.org/10.1016/j.bbamem.2017.08.016

Torsten John, Zhi Xiang Voo, Clemens Kubeil, Bernd Abel, Bim Graham, Leone Spiccia, Lisandra L Martin (2017). Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance. MedChemComm. https://doi.org/10.1039/C7MD00054E

Prof. Dr. Torsten John
Prof. Dr. Torsten John
Assistant Professor of Physical Chemistry

We are committed to advancing the understanding of biomolecular behavior and leveraging this knowledge to engineer bionanomaterials.